Journal article
Brain White Matter Development over the First 13 Years in Very Preterm and Typically Developing Children Based on the T 1-w/ T 2-w Ratio
DK Thompson, JYM Yang, J Chen, CE Kelly, CL Adamson, B Alexander, C Gilchrist, LG Matthews, KJ Lee, RW Hunt, JLY Cheong, M Spencer-Smith, JJ Neil, ML Seal, TE Inder, LW Doyle, PJ Anderson
Neurology | Published : 2022
Abstract
Background and ObjectivesTo investigate brain regional white matter development in full-term (FT) and very preterm (VP) children at term equivalent and 7 and 13 years of age based on the ratio of T1- and T2-weighted MRI (T1-w/T2-w), including (1) whether longitudinal changes differ between birth groups or sexes, (2) associations with perinatal risk factors in VP children, and (3) relationships with neurodevelopmental outcomes at 13 years.MethodsProspective longitudinal cohort study of VP (born <30 weeks' gestation or <1,250 g) and FT infants born between 2001 and 2004 and followed up at term equivalent and 7 and 13 years of age, including MRI studies and neurodevelopmental assessments. T1-w/..
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Grants
Awarded by National Institutes of Health
Funding Acknowledgements
This study was supported by the Australian National Health and Medical Research Council (Centre for Clinical Research Excellence 546519, 1060733, and 1153176; project grants 237117, 491209, and 1066555; Senior Research Fellowship 1081288 and Leadership Fellowship 1176077 to P.A.; Career Development Fellowship 1085754 and 1160003 to D.T., 1141354 to J.L.Y.C., and 1127984 to K.J.L.; Early Career Fellowship 1012236 to D.T.), US National Institutes of Health HD058056, United Cerebral Palsy Foundation, Leila Y. Mathers Charitable Foundation, the Brown Foundation, Murdoch Children's Research Institute, The Royal Children's Hospital, The Royal Children's Hospital Foundation (RCH1000 to J.Y.-M.Y.), Department of Paediatrics, The University of Melbourne, the Victorian Government's Operational Infrastructure Support Program, and an Australian Government Research Training Program scholarship and Monash Graduate Excellence Scholarship (to C.K.).